opsmode

When using a management pack designed to discover a 32bit application and that application is installed on a 64bit server OS the application will probably not get discovered.

This is because the 32bits app will write its registry keys in the HKLM\SOFTWARE\Wow6432Node\ (because its a 32bit app on a 64bit system) and the discovery will look for keys and values in HKLM\SOFTWARE\

To resolve this you can either create the registry keys under HKLM\SOFTWARE or install a 32bit agent on the system.
If you install the 32bit agent it will bee replaced every time you do a upgrade from the console, and worse you wont bee able to monitor your 64bit system properly.

When author MP’s for OpsMgr 2007 R2 there is a new feature that can be used in the discovery.
<RegistryView>32bit</RegistryView>

Should go somthing like this:

<RegistryAttributeDefinition>
  <AttributeName>TheApplication</AttributeName>
  <Path>SOFTWARE\TheApplication</Path>
  <PathType>0</PathType>
  <AttributeType>0</AttributeType>
  <RegistryView>32bit</RegistryView>
</RegistryAttributeDefinition>

And this will make it look in the Wow6432Node